Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8'-hydroxylase CYP707A.

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Title:	Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8'-hydroxylase CYP707A.
Authors:	Okazaki, Mariko Nimitkeatkai, Hataitip Muramatsu, Taku Aoyama, Hikaru Ueno, Kotomi Mizutani, Masaharu Hirai, Nobuhiro Kondo, Satoru Ohnishi, Toshiyuki Todoroki, Yasushi
Journal Title:	Bioorganic & Medicinal Chemistry
Publisher:	Elsevier
Journal Volume:	19
Journal Issue:	1
Start Page:	406
End Page:	413
Issue Date:	2011-01-01
Rights:	Copyright © 2010 Elsevier Ltd All rights reserved.
NDC:	471
Abstract:	We developed abscinazole-E1 (Abz-E1), a specific inhibitor of abscisic acid (ABA) 8'-hydroxylase (CYP707A). This inhibitor was designed and synthesized as an enlarged analogue of uniconazole (UNI), a well-known plant growth retardant, which inhibits a gibberellin biosynthetic enzyme (ent-kaurene oxidase, CYP701A) as well as CYP707A. Our results showed that Abz-E1 functions as a potent inhibitor of CYP707A and a poor inhibitor of CYP701A both in vitro and in vivo. Abz-E1 application to plants resulted in improved desiccation tolerance and an increase in endogenous ABA.
ISSN:	09680896
DOI:	10.1016/j.bmc.2010.11.011
PMID:	21115253
Journal NCID:	AA10938083
Textversion:	author
Appears in Collections:	06. 雑誌論文・記事(Journal Article, Article, Preprint)

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Others By: Okazaki, Mariko -- Nimitkeatkai, Hataitip -- Muramatsu, Taku -- Aoyama, Hikaru -- Ueno, Kotomi -- Mizutani, Masaharu -- Hirai, Nobuhiro -- Kondo, Satoru -- Ohnishi, Toshiyuki -- Todoroki, Yasushi (轟, 泰司) (トドロキ, ヤスシ)