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Title: Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8'-hydroxylase CYP707A.
Authors: Okazaki, Mariko
Nimitkeatkai, Hataitip
Muramatsu, Taku
Aoyama, Hikaru
Ueno, Kotomi
Mizutani, Masaharu
Hirai, Nobuhiro
Kondo, Satoru
Ohnishi, Toshiyuki
Todoroki, Yasushi
Journal Title: Bioorganic & Medicinal Chemistry
Publisher: Elsevier
Journal Volume: 19
Journal Issue: 1
Start Page: 406
End Page: 413
Issue Date: 2011-01-01
Rights: Copyright © 2010 Elsevier Ltd All rights reserved.
NDC: 471
Abstract: We developed abscinazole-E1 (Abz-E1), a specific inhibitor of abscisic acid (ABA) 8'-hydroxylase (CYP707A). This inhibitor was designed and synthesized as an enlarged analogue of uniconazole (UNI), a well-known plant growth retardant, which inhibits a gibberellin biosynthetic enzyme (ent-kaurene oxidase, CYP701A) as well as CYP707A. Our results showed that Abz-E1 functions as a potent inhibitor of CYP707A and a poor inhibitor of CYP701A both in vitro and in vivo. Abz-E1 application to plants resulted in improved desiccation tolerance and an increase in endogenous ABA.
ISSN: 09680896 OPAC
DOI: 10.1016/j.bmc.2010.11.011   
PMID: 21115253
Journal NCID: AA10938083 OPAC ciniib
Textversion: author
Appears in Collections:06. 雑誌論文・記事(Journal Article, Article, Preprint)

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Others By: Okazaki, Mariko -- Nimitkeatkai, Hataitip -- Muramatsu, Taku -- Aoyama, Hikaru -- Ueno, Kotomi -- Mizutani, Masaharu -- Hirai, Nobuhiro -- Kondo, Satoru -- Ohnishi, Toshiyuki -- Todoroki, Yasushi (轟, 泰司) (トドロキ, ヤスシ)

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