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タイトル: Studies on sea snake venom
著者: Tamiya, Nobuo
Yagi, Tatsuhiko
掲載誌名: Proceedings of the Japan Academy. Series B
出版者: The Japan Academy
巻: 87
号: 3
開始ページ: 41
終了ページ: 52
出版日付: 2011
権利: Copyright © 2011 The Japan Academy
NDC: 464
抄録: Erabutoxins a and b are neurotoxins isolated from venom of a sea snake Laticauda semifasciata (erabu-umihebi). Amino acid sequences of the toxins indicated that the toxins are members of a superfamily consisting of short and long neurotoxins and cytotoxins found in sea snakes and terrestrial snakes. The short neurotoxins to which erabutoxins belong act by blocking the nicotinic acetylcholine receptor on the post synaptic membrane in a manner similar to that of curare. X-ray crystallography and NMR analyses showed that the toxins have a three-finger structure, in which three fingers made of three loops emerging from a dense core make a gently concave surface of the protein. The sequence comparison and the location of essential residues on the protein suggested the mechanism of binding of the toxin to the acetylcholine receptor. Classification of snakes by means of sequence comparison and that based on different morphological features were inconsistent, which led the authors to propose a hypothesis "Evolution without divergence."(Communicated by Satoshi OMURA, M.J.A.).
ISSN: 03862208 OPAC
E-ISSN: 13492896 OPAC
出版者DOI: 10.2183/pjab.87.41   
PMID: 21422738
NII論文ID: 130000669109 ciniia
NII書誌ID: AA00785485 OPAC ciniib
バージョン: publisher
出現コレクション:02. 雑誌論文・記事(Journal Article, Article, Preprint)

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