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タイトル: Chiasmata Promote Monopolar Attachment of Sister Chromatids and Their Co-Segregation toward the Proper Pole during Meiosis I
著者: Hirose, Yukinobu
Suzuki, Ren
Ohba, Tatsunori
Hinohara, Yumi
Matsuhara, Hirotada
Yoshida, Masashi
Itabashi, Yuta
Murakami, Hiroshi
Yamamoto, Ayumu
掲載誌名: PLoS Genetics
出版者: Public Library of Science
巻: 7
号: 3
開始ページ: e1001329
出版日付: 2011-03-10
権利: © 2011 Hirose et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
NDC: 463
抄録: The chiasma is a structure that forms between a pair of homologous chromosomes by crossover recombination and physically links the homologous chromosomes during meiosis. Chiasmata are essential for the attachment of the homologous chromosomes to opposite spindle poles (bipolar attachment) and their subsequent segregation to the opposite poles during meiosis I. However, the overall function of chiasmata during meiosis is not fully understood. Here, we show that chiasmata also play a crucial role in the attachment of sister chromatids to the same spindle pole and in their co-segregation during meiosis I in fission yeast. Analysis of cells lacking chiasmata and the cohesin protector Sgo1 showed that loss of chiasmata causes frequent bipolar attachment of sister chromatids during anaphase. Furthermore, high time-resolution analysis of centromere dynamics in various types of chiasmate and achiasmate cells, including those lacking the DNA replication checkpoint factor Mrc1 or the meiotic centromere protein Moa1, showed the following three outcomes: (i) during the pre-anaphase stage, the bipolar attachment of sister chromatids occurs irrespective of chiasma formation; (ii) the chiasma contributes to the elimination of the pre-anaphase bipolar attachment; and (iii) when the bipolar attachment remains during anaphase, the chiasmata generate a bias toward the proper pole during poleward chromosome pulling that results in appropriate chromosome segregation. Based on these results, we propose that chiasmata play a pivotal role in the selection of proper attachments and provide a backup mechanism that promotes correct chromosome segregation when improper attachments remain during anaphase I.
ISSN: 15537390 OPAC
出版者DOI: 10.1371/journal.pgen.1001329   
PMID: 21423721
NII書誌ID: AA12073492 OPAC ciniib
バージョン: publisher
出現コレクション:04. 雑誌論文・記事(Journal Article, Article, Preprint)

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Others By: Hirose, Yukinobu -- Suzuki, Ren -- Ohba, Tatsunori -- Hinohara, Yumi -- Matsuhara, Hirotada -- Yoshida, Masashi -- Itabashi, Yuta -- Murakami, Hiroshi -- Yamamoto, Ayumu (山本, 歩) (ヤマモト, アユム)

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