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タイトル: Kinetics of low pH-induced lamellar to bicontinuous cubic phase transition in dioleoylphosphatidylserine/monoolein
著者: Alam, Mahay Md.
Oka, Toshihiko
Ohta, Noboru
Yamazaki, Masahito
掲載誌名: Journal of Chemical Physics
出版者: American Institute of Physics
巻: 134
号: 14
開始ページ: 145102
出版日付: 2011-04-12
権利: © 2011 American Institute of Physics
NDC: 464
抄録: Recently, it has been well recognized that the modulation of electrostatic interactions due to surface charges can induce transitions between lamellar liquid-crystalline (L(α)) and inverse bicontinuous double-diamond cubic (Q(II) (D)) phases in biological lipids. To reveal their kinetic pathway and mechanism, we investigated the low pH-induced L(α) to Q(II) (D) phase transitions in 20%-dioleoylphosphatidylserine (DOPS)/80%-monoolein (MO) using time-resolved small-angle x-ray scattering and a rapid mixing method. At a final pH of 2.6-2.9, the L(α) phase was transformed completely into the hexagonal II (H(II)) phase within 2-10 s after mixing a low pH buffer with a suspension of multilamellar vesicles of 20%-DOPS∕80%-MO (the initial step). Subsequently, the H(II) phase slowly converted into the Q(II) (D) phase and completely disappeared within 15-30 min (the second step). The rate constants of the second step were obtained using the singular value decomposition analysis. On the basis of these data, we discuss the underlying mechanism of the kinetic pathway of the low pH-induced L(α) to Q(II) (D) phase transitions.
ISSN: 00219606 OPAC
出版者DOI: 10.1063/1.3575240   
PMID: 21495771
NII書誌ID: AA00694991 OPAC ciniib
バージョン: publisher
出現コレクション:11. 雑誌論文・記事(Journal Article, Article, Preprint)

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Others By: Alam, Mahay Md. -- Oka, Toshihiko (岡, 俊彦) (オカ, トシヒコ) -- Ohta, Noboru -- Yamazaki, Masahito (山崎, 昌一) (ヤマザキ, マサヒト)



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