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タイトル: The inhibitory effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activities of mushroom tyrosinase
著者: Sato, Kazuomi
Toriyama, Masaru
掲載誌名: International Journal of Molecular Sciences
出版者: MDPI
巻: 12
号: 6
開始ページ: 3998
終了ページ: 4008
出版日付: 2011-06-14
権利: © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (
NDC: 464
抄録: In the present work, we investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activity of mushroom tyrosinase. The results showed that diflunisal and indomethacin inhibited both monophenolase and diphenolase activity. For monophenolase activity, the lag time was extended in the presence of diflunisal. In the presence of indomethacin, the lag time did not change. IC(50) values of monophenolase activity were estimated to be 0.112 mM (diflunisal) and 1.78 mM (indomethacin). Kinetic studies of monophenolase activity revealed that both diflunisal and indomethacin were non-competitive inhibitors. For diphenolase activity, IC(50) values were estimated to be 0.197 mM (diflunisal) and 0.509 mM (indomethacin). Diflunisal and indomethacin were also found to be non-competitive diphenolase inhibitors.
E-ISSN: 14220067 OPAC
出版者DOI: 10.3390/ijms12063998   
PMID: 21747720
NII書誌ID: AA12038549 OPAC ciniib
バージョン: publisher
出現コレクション:06. 雑誌論文・記事(Journal Article, Article, Preprint)

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